July 15, 2025

Supplementary Figure 3 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Authors

CLCatrin LutzThe Netherlands Cancer Institute XCXue ChaoSun Yat-sen University BKBim de KleinUtrecht University

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Implication

Pathology analyses reveal TGFβ signaling influences tumor morphology and aggressiveness in breast cancer xenografts, highlighting its regulatory role.

Key Points

TGFβ signaling is identified as a crucial factor in breast cancer morphology and aggressiveness.
Large-scale characterization of cell line-derived xenografts was performed to assess tumor behavior.
Pathology analyses focused on MIND-CDX tumors to understand the impact of TGFβ signaling.
Findings suggest that targeting TGFβ signaling could be significant for breast cancer treatment strategies.

Cite This Study

Lutz et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6e2 https://doi.org/10.1158/0008-5472.29568112

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Implication

Pathology analyses reveal TGFβ signaling influences tumor morphology and aggressiveness in breast cancer xenografts, highlighting its regulatory role.

Supplementary Figure 3 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

Discussion

Member takes

Implication

Key Points

Cite This Study

Supplementary Figure 3 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

Discussion

Member takes

Implication

Key Points

Cite This Study

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