July 15, 2025

Supplementary Figure 9 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Discussion

Large-scale analysis shows TGFβ signaling impacts breast cancer morphology and estrogen influence on tumors.

TGFβ signaling is identified as a significant regulator of breast cancer aggressiveness and morphology.
The influence of estrogen on MIND-CDX tumors provides insights into hormonal effects on cancer.
Orthotopic cell line-derived xenografts were utilized to model breast cancer behavior in a controlled environment.
Understanding TGFβ signaling can lead to improved therapeutic approaches for aggressive breast cancer.

Lutz et al. (2025) studied this question.

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