July 15, 2025

Supplementary Figure 5 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Discussion

Xenograft models reveal TGFβ signaling influences tumor growth and morphology in breast cancer, indicating clinical relevance.

TGFβ signaling plays a crucial role in regulating the morphology and aggressiveness of breast cancer tumors.
The study utilized MIND-CDX models to evaluate tumor growth kinetics over time.
Orthotopic cell line-derived xenografts offer valuable insights into breast cancer behavior and treatment responses.
Understanding TGFβ signaling could lead to better therapeutic strategies targeting tumor progression in breast cancer.

Lutz et al. (2025) studied this question.

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