July 15, 2025

Supplementary Figure 11 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Discussion

Figure reveals TGF-beta signaling's role in shaping breast cancer morphology and aggressiveness, indicating potential therapeutic targets.

Main finding reveals that TGF-beta signaling significantly influences breast cancer morphology and aggressiveness.
Evidence shows that both autocrine and paracrine TGF-beta signaling contribute to nodular growth in cancer cells.
The approach utilized large-scale characterization of xenografts derived from orthotopic cell lines in this study.
This insight could lead to improved therapeutic strategies targeting TGF-beta signaling in breast cancer management.

Lutz et al. (2025) studied this question.

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Figure reveals TGF-beta signaling's role in shaping breast cancer morphology and aggressiveness, indicating potential therapeutic targets.