July 15, 2025

Supplementary Figure 12 from Large-scale Characterization of Orthotopic Cell Line–Derived Xenografts Identifies TGFβ Signaling as a Key Regulator of Breast Cancer Morphology and Aggressiveness

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Discussion

Supplementary figure reveals angiogenesis impacts tumor morphology in xenograft models, suggesting TGFβ signaling's role in aggressiveness.

MAIN FINDING: Angiogenesis significantly influences tumor growth morphology in breast cancer models.
KEY EVIDENCE: Data from xenograft studies show distinct morphological changes linked to TGFβ signaling.
APPROACH: The analysis involved large-scale characterizations of orthotopic cell line-derived xenografts.
SIGNIFICANCE: Understanding angiogenesis as a regulator may inform new therapeutic strategies for aggressive breast cancer.

Lutz et al. (2025) studied this question.

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Supplementary figure reveals angiogenesis impacts tumor morphology in xenograft models, suggesting TGFβ signaling's role in aggressiveness.