Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

Lingjiao Meng; Haotian Wu; Jiaxiang Wu; Ping’an Ding; Jinchen He; Tongkun Li; Xiaoman Niu; Meixiang Sang; Lihua Liu

doi:10.1158/0008-5472.29567954

July 15, 2025

Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

View at Publisher

Ask AI

Bookmark

Share

Key Points

MAIN FINDING: CircTMEM45A is linked to inflammatory progression in esophageal carcinoma through NLRP3 activation.
KEY EVIDENCE: m5C modifications on circTMEM45A and NLRP3 were identified via predictive tools and confirmed by RIP assay.
APPROACH: Techniques included predictions from StarBase and m5Cfinder along with experimental assays in KYSE150 cells.
SIGNIFICANCE: Understanding these pathways may help develop targeted therapies for managing esophageal carcinoma progression.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Findings reveal circTMEM45A activates NLRP3 through m5C modifications in esophageal carcinoma, suggesting inflammatory pathways contribute to cancer progression.

Abstract

Supplementary Figure 7. Prediction of m5C modification sites of circTMEM45A and NLRP3. (A) StarBase predicts the binding potential of circTMEM45A to miRNAs. (B) RNAm5Cfinder predicts m5C modifications in circTMEM45A. (C-D) m5C Atlas and RMDisease predict m5C modifications in NLRP3. (E-F) RIP assay demonstrating the enrichment of circTMEM45A (E) and NLRP3 (F) by m5C antibody in KYSE150 cells. ns: not significant, ***P<0.001.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc654 https://doi.org/10.1158/0008-5472.29567954

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure 7 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading