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July 15, 2025

Supplementary Figure 5 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Observations demonstrate circTMEM45A affects lymphangiogenesis and angiogenesis in esophageal squamous cell carcinoma, suggesting links to inflammatory progression.

Key Points

  • MAIN FINDING: circTMEM45A influences inflammatory progression in esophageal squamous cell carcinoma through NLRP3 activation.
  • KEY EVIDENCE: Migration assays reveal significant differences in lymphangiogenesis in cells with circTMEM45A silenced.
  • APPROACH: HLECs and HUVECs were co-cultured with circTMEM45A-silenced KYSE150 cells to assess effects on migration and angiogenesis.
  • SIGNIFICANCE: Understanding these mechanisms may reveal new targets for treating esophageal squamous cell carcinoma.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc640https://doi.org/10.1158/0008-5472.29567960
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