Supplementary Figure 3 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

Supplementary Figure 3. Relationship between circTMEM45A expression and clinical characteristics. (A-B) Consistency test of FISH interpretation by two investigators. (C) The correlation between circTMEM45A expression and age, pathological grade, or gender of ESCC patients in the tissue microarray set. (D) Univariate COX regression analysis of ESCC patient prognosis. (E) Representative FISH images of ESCC tissues. (F-G) Consistency test of FISH interpretation for the external validation set by two investigators. (H) The comparison of circTMEM45A expression between normal tissues and ESCC tissues, as well as the correlation between circTMEM45A expression and tumor size, T stage, N stage, or TNM stage of ESCC patients in the external validation set. (I) The correlation between circTMEM45A expression and age, pathological grade, or gender of ESCC patients in the external validation set. *P<0.05, **P<0.01.