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July 15, 2025

Supplementary Figure 10 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

RAP assay shows circTMEM45A enhances NLRP3 activation in esophageal cells, indicating its role in cancer progression.

Key Points

  • Aberrant circTMEM45A influences the inflammatory progression in esophageal squamous cell carcinoma.
  • CircTMEM45A interacts with U2AF2 protein, impacting IL1B expression in KYSE150 cells.
  • Both qRT-PCR and western blot analyses validate the overexpression and silencing effects on U2AF2.
  • Findings suggest circTMEM45A's role in promoting cancer inflammation, intersecting with cellular pathways.
  • ],

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc678https://doi.org/10.1158/0008-5472.29567984
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