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July 15, 2025

Supplementary Figure 9 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

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Authors

LMLingjiao MengHWHaotian WuJWJiaxiang Wu

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Overview

Experimental analysis reveals circTMEM45A enhances NLRP3 activation in esophageal squamous cell carcinoma, highlighting its role in tumor progression.

Key Points

  • Main finding indicates circTMEM45A promotes NLRP3 activation, fueling inflammatory responses in esophageal squamous cell carcinoma.
  • Data shows knockdown of NSUN2, ALYREF, and YBX1 in KYSE150 cells significantly decreases circTMEM45A expression levels.
  • Methods included qRT-PCR and western blot for protein and mRNA measurements in various cell lines to assess interactions.
  • This research provides insights into the molecular mechanisms of circTMEM45A in cancer biology, proposing new therapeutic targets.

Cite This Study

Meng et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6c1https://doi.org/10.1158/0008-5472.29567945
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Supplementary Figure 10 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  2. 2Supplementary Figure 11 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  3. 3Supplementary Figure 6 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  4. 4Supplementary Figure 13 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025
  5. 5Supplementary Figure 4 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation2025