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Bioinformatics analysis reveals m5C gene expression and immune cell interactions in esophageal squamous cell carcinoma, suggesting a role in disease progression.
Supplementary Figure 8. Bioinformatics analysis revealed the characteristics of m5C genes, functional analysis, and correlation with immune cells. (A) The heat map displaying the differential expression of 15 m5C-related genes in ESCC tissues compared to adjacent tissues. (B-D) Violin and bubble plots illustrating the differential expression and pathway enrichment of NSUN2 (B), ALYREF (C), and YBX1 (D) in ESCC tissues compared to adjacent tissues. (E-G) Correlation analysis of NSUN2 (E), ALYREF (F), and YBX1 (G) with immune cell populations. (H) The specific peptide maps for NSUN2, ALYREF, and YBX1 identified by MS. ***P<0.001.
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Meng et al. (2025) studied this question.
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