Bioinformatics analysis reveals m5C gene expression and immune cell interactions in esophageal squamous cell carcinoma, suggesting a role in disease progression.
Key Points
Aberrant m5c genes facilitate the progression of esophageal squamous cell carcinoma via NLRP3 activation.
Differential expression of 15 m5C-related genes was observed in ESCC tissues compared to adjacent tissues.
Correlation between NSUN2, ALYREF, and YBX1 with immune cell populations was analyzed, showing significant associations.
This research highlights the importance of m5C gene activity in cancer immunity, potentially guiding future therapies.