Supplementary Figure 1 from Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation

Supplementary Figure 1. Differentially expressed circRNAs in human ESCC and adjacent normal tissues. (A) Ratios of circRNAs derived from different regions identified in ESCC and adjacent normal tissue samples. (B) Lengths of different circRNAs identified in ESCC and adjacent normal tissue samples. (C) Violin plots of circRNA expression distribution in each tissue group. (D) Based on the threshold (pvalue<0.05 and |log2FoldChange|>0), there were 393 differentially expressed circRNAs in ESCC tissues compared with adjacent normal tissues (158 circRNAs were upregulated and 235 circRNAs were downregulated). (E) Volcano plots showing the overall expression changes of circRNAs in tumor tissues and adjacent normal tissues (The scatter points shown in the volcano plot exclude inf values). (F) Heat maps showing the clustering patterns of differentially expressed circRNAs in each tissue. (G-H) Bubble plots showing the results of GO (G) and KEGG (H) enrichment analysis of differentially expressed circRNAs.