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Supplementary analysis reveals circTMEM45A interacts with IGF2BP2 and HUR, facilitating NLRP3 activation in esophageal squamous cell carcinoma.
Supplementary Figure 12. Prediction of binding sites of circTMEM45A-IGF2BP2 and circTMEM45A-HUR. (A) Predicted secondary structure of circTMEM45A. (B-C) HDOCK-predicted spatial structures of circTMEM45A binding with IGF2BP2 and HUR. (D) Predicted binding sites between circTMEM45A and IGF2BP2. (E-F) Predicted binding sites between circTMEM45A and HUR. (G-H) Sequence of hsa_circ_0066658-Mut2(IGF2BP2) and hsa_circ_0066658-Mut1(HUR) vectors.
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Meng et al. (2025) studied this question.
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