Supplementary Figure S1 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enßle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger

doi:10.1158/0008-5472.29567891

July 15, 2025

Supplementary Figure S1 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

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Key Points

MAIN FINDING: Targeting intracellular RNA-sensing systems enhances the effectiveness of CAR T-cell therapy in solid tumors.
KEY EVIDENCE: Co-culture of CAR T cells with tumor cells shows increased RIG-I and MAVS protein levels, suggesting improved immunogenic response.
APPROACH: Examined MAVS protein abundance and transcriptional changes in tumor cells through experimental co-culture methods.
SIGNIFICANCE: Overcoming resistance in solid tumors can lead to more effective CAR T-cell therapies, improving patient outcomes.

Implication

Co-culture demonstrates upregulation of RIG-I and MAVS in tumor cells, indicating resistance overcoming potential in CAR T-cell therapy.

Abstract

MAVS protein abundance, baseline RIG-I protein expression, and the transcriptional upregulation of RIG-I/MAVS pathway components, pro-apoptotic mediators, and death receptors in tumor cells after co-culture with CAR T cells

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Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc656 https://doi.org/10.1158/0008-5472.29567891

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Supplementary Figure S1 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

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