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July 15, 2025

Supplementary Figure S3 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman Tatiana Nedelko Giada Mandracci Stefan Enßle Vincent Grass Julius Fischer Florian Bassermann Hendrik Poeck Sebastian Kobold Nadia El Khawanky Simon Heidegger

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Key Points

MAIN FINDING: Induction of apoptosis was observed in tumor cells, enhancing responses to CAR T-cell therapy.
KEY EVIDENCE: Mavs-defective murine PDAC and human lung adenocarcinoma cells underwent significant apoptosis during treatment.
APPROACH: This research utilized CAR T-cell therapy to target intracellular RNA-sensing systems in solid tumors.
SIGNIFICANCE: The findings suggest novel strategies for overcoming resistance to CAR T-cell therapy in challenging solid tumors.

Implication

Research demonstrates apoptosis in tumor cells with CAR T-cell treatment, indicating RNA-sensing systems impact therapy efficacy.

Abstract

Induction of apoptosis in murine PDAC and human lung adenocarcinoma Mavs-defective tumor cells in response to CAR T cell-mediated killing

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Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc697 https://doi.org/10.1158/0008-5472.29567882

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S6 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
2Supplementary Figure S5 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
3Supplementary Figure S9 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
4Supplementary Figure S2 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
5Supplementary Figure S1 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025