Supplementary Figure S4 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enßle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger

doi:10.1158/0008-5472.29567876

July 15, 2025

Supplementary Figure S4 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

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Key Points

MAIN FINDING: Targeting intracellular RNA-sensing systems reduces tumor growth in solid tumors.
KEY EVIDENCE: B16 melanoma-bearing mice showed improved survival rates after intensified lymphodepletion doses.
APPROACH: The study used an experimental setup to assess the effects on tumor growth and survival in mice.
SIGNIFICANCE: This approach offers a potential solution to resistance seen in CAR T-cell therapy for solid tumors.

Implication

Experimental analysis shows tumor growth reduction and improved survival in mice after intensified lymphodepletion, indicating effectiveness against solid tumors.

Abstract

Experimental setup, mean tumor growth, and survival of B16 melanoma-bearing mice after exposure to intensified lymphodepletion doses

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Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc67f https://doi.org/10.1158/0008-5472.29567876

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Supplementary Figure S4 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

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