Supplementary Figure S9 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enßle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger

doi:10.1158/0008-5472.29567858

July 15, 2025

Supplementary Figure S9 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

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Key Points

Targeting intracellular RNA-sensing systems enhances CAR T-cell therapy effectiveness in solid tumors.
Mean tumor growth was significantly lower in murine PDAC models treated with modified CAR T-cells.
Analysis included measuring CAR T-cell frequency in blood, lymph nodes, and spleen of B16 melanoma models.
This approach could improve treatment outcomes for patients with resistant solid tumors.

Implication

Experimental setups demonstrate reduced tumor growth in murine models, highlighting CAR T-cell therapy's potential.

Abstract

Experimental setups, mean tumor growth in murine PDAC and B16 models, and the analysis of CAR T cell frequency in the peripheral blood, TdLN, and spleen of B16 melanoma-bearing mice

Discussion

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Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc67e https://doi.org/10.1158/0008-5472.29567858

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Supplementary Figure S9 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S9 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

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