Supplementary Figure S2 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enßle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger

doi:10.1158/0008-5472.29567888

July 15, 2025

Supplementary Figure S2 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

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Key Points

Main finding reveals that targeting intracellular innate RNA-sensing systems enhances car t-cell therapy efficacy.
Cytolytic function of car t cells showed improvement following exposure to mavs-defective tumor cells.
Assessment of exhaustion markers and activation molecules provided insights on immune response mechanisms.
Significance lies in identifying strategies to overcome resistance in solid tumors for more effective treatments.

Implication

Research demonstrates improved cytolytic function in CAR T cells exposed to mavs-defective tumor cells, indicating potential to overcome resistance.

Abstract

Expression frequency of exhaustion markers and activation molecules and assessment of CAR T cell cytolytic function after exposure to Mavs-defective tumor cells

Discussion

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Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc668 https://doi.org/10.1158/0008-5472.29567888

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Supplementary Figure S2 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

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