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July 15, 2025

Supplementary Figure S7 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman Tatiana Nedelko Giada Mandracci Stefan Enßle Vincent Grass Julius Fischer Florian Bassermann Hendrik Poeck Sebastian Kobold Nadia El Khawanky Simon Heidegger

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Key Points

Main finding shows targeting intracellular RNA-sensing enhances CAR T-cell therapy efficacy in solid tumors.
Key evidence indicates transcriptional upregulation of pro-apoptotic mediators and IFN-I in treated cells.
Approach involved co-culturing CAR T cells with Panc02 cells in 3pRNA-conditioned medium to assess apoptosis.
Significance lies in overcoming resistance to CAR T-cell therapy, advancing treatment strategies for solid tumors.

Implication

Research demonstrates increased apoptosis in solid tumors with CAR T-cell therapy, indicating RNA-sensing systems may reduce therapy resistance.

Abstract

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Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc6a3 https://doi.org/10.1158/0008-5472.29567864

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S6 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
2Supplementary Figure S3 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
3Supplementary Figure S9 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
4Supplementary Figure S1 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025
5Supplementary Figure S8 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors2025