Supplementary Figure S6 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Nardine Soliman; Tatiana Nedelko; Giada Mandracci; Stefan Enßle; Vincent Grass; Julius C. Fischer; Florian Bassermann; Hendrik Poeck; Sebastian Kobold; Nadia El Khawanky; Simon Heidegger

doi:10.1158/0008-5472.29567867

July 15, 2025

Supplementary Figure S6 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

View at Publisher

Ask AI

Bookmark

Share

Key Points

Main finding shows that targeting intracellular RNA-sensing systems can overcome resistance to CAR T-cell therapy in solid tumors.
Key evidence includes the transcriptional upregulation of death receptors and apoptosis induction in B16 cells.
Approach involved treating murine PDAC tumor cells with 3pRNA liposomes and analyzing apoptosis using FACS.
Significance lies in improving therapeutic efficacy of CAR T-cell therapy for challenging solid tumors.

Implication

Research demonstrates apoptosis induction in tumor cells, suggesting that targeting RNA-sensing may enhance CAR T-cell therapy.

Abstract

Transcriptional upregulation of death receptors on tumor cells, apoptosis induction in B16 cells with or without wash-off of 3pRNA liposomes and in murine PDAC tumor cells, and representative FACS blots for the analysis of apoptosis induction and EpCAM expression on tumor cells

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Soliman et al. (2025) studied this question.

synapsesocial.com/papers/689a02bce6551bb0af8cc680 https://doi.org/10.1158/0008-5472.29567867

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure S6 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from Targeting Intracellular Innate RNA-Sensing Systems Overcomes Resistance to CAR T-cell Therapy in Solid Tumors

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading