RNA-seq analysis shows MPZL3 knockdown impacts gene expression in ovarian cancer cells, suggesting EMT involvement.
RNA-seq analysis following MPZL3 knockdown. A, Distribution of selected differentially expressed genes (DEG) in OVCAR4 and OVCA433 cells following MPZL3 knockdown (threshold: adjusted P value < 0.05, log₂ fold change ≥1). B, Venn diagram of the number of significantly downregulated and upregulated DEGs in OVCA433 and OVCAR4 cells following MPZL3 knockdown. C, Enriched hallmark pathways commonly altered in OVCA433 and OVCAR4 cells following MPZL3 knockdown (MSigDB analysis of shared DEGs).
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Cheng et al. (2025) studied this question.
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