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July 21, 2025

Supplementary Figure S4 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer

Ya-Yun Cheng Beth L. Worley Zaineb Javed Amal T. Elhaw Priscilla W. Tang Sarah Al-Saad Shriya Kamlapurkar Sierra R. White Apoorva Uboveja Karthikeyan Mythreye Katherine M. Aird Traci A. Czyzyk Nadine Hempel

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Key Points

LOSS OF MPZL3: Loss of the cell adhesion molecule MPZL3 promotes epithelial-mesenchymal transition (EMT) in ovarian cancer.
DRUG RESPONSE: Dose-response curves demonstrate the effects of cisplatin and olaparib on OVCA433 cells.
KNOCKDOWN IMPACT: MPZL3 knockdown modifies cell behavior and drug effectiveness in ovarian cancer models.
CLINICAL SIGNIFICANCE: Understanding MPZL3's role may guide more effective therapeutic strategies in ovarian cancer.

Implication

Observational data shows MPZL3 knockdown alters drug response in ovarian cancer cells, indicating potential treatment implications.

Abstract

Supplementary Figure S4. Dose-response curves of cisplatin and olaparib in OVCA433 cells following MPZL3 knockdown.

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Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd1ef https://doi.org/10.1158/2767-9764.29607294

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer2025
2Supplementary Figure S2 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer2025
3Figure 6 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer2025
4Supplementary Figure S1 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer2025
5Figure 2 from Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer2025