Supplementary Figure S4 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Can Chen; Yimin Cai; Wenlong Hu; Kai Tan; Zequn Lu; Xuanyu Zhu; Ziying Liu; Chunyi He; Guangping Xu; Ruizhe Zhang; Caibo Ning; Shuheng Ruan; Jiayan Gao; Xiaojun Yang; Yongchang Wei; Xu Zhu; Xiangpan Li; Faxi Wang; Fubing Wang; Jiaoyuan Li; Meng Jin; Bin Li; Ying Zhu; Jianbo Tian; Xiaoping Miao

doi:10.1158/2159-8290.29819592

Key Points

Single-cell eqtl mapping reveals cell subtype-specific genetic control in colorectal cancer.
Immunohistochemistry shows ASCL2 and LGR5 expression patterns across different stages of tumorigenesis.
Supplementary figure demonstrates how malignant transformation is influenced by genetic factors.
Findings suggest potential targets for therapies aimed at colorectal cancer interventions.

Implication

Supplementary figure illustrates genetic control mechanisms in colorectal cancer, highlighting ASCL2 and LGR5 in tumorigenesis.

Abstract

Supplementary Figure 4 shows representative images showing immunohistochemistry staining of ASCL2 (top) and LGR5 protein (bottom) in samples of different stages of CRC tumorigenesis.

Discussion

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/689a0f86e6551bb0af8d096a https://doi.org/10.1158/2159-8290.29819592

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Supplementary Figure S4 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from Single-cell eQTL Mapping Reveals Cell Subtype–specific Genetic Control and Mechanism in Malignant Transformation of Colorectal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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