Figure 3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Disturbances in the intestinal tract of Eμ-TCL1 mice with advanced CLL disease. A, Representative hematoxylin and eosin images of small intestine tissue in WT B6 and Eμ-TCL1 mice at 12 months (n = 7–13 mice/genotype). Hematoxylin and eosin stains: scale bar, 100 μm (left and middle) and 200 pixels (right). B and C, Representative images of small intestine (serial sections) from 12-month-old WT B6 and Eμ-TCL1 mice (n = 4–5 mice/genotype) stained with antibody against human TCL1 (B) and murine CD19 (C). Histoscore data are presented as violin plots illustrating the empirical distribution of data. The black, dashed line represents the median. Asterisks denote the significance of the histoscores between WT B6 and Eμ-TCL1 mice (***, P < 0.001). Unpaired Welch t test was applied for testing.