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August 15, 2025Open Access

Supplementary Figure S2 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Sydney A. Skupa Kathryn Cooper Audrey L. Smith Erin M. Drengler Alexandria P. Eiken Elizabeth Schmitz Grace M. Waldron Grinu Mathew Mark Primeaux Punita Dhawan Geoffrey A. Talmon Christopher R. D’Angelo Dalia El-Gamal

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Key Points

Chronic lymphocytic leukemia is associated with a specific dysbiotic signature in Eµ-TCL1 mice.
Relative abundance of gut microbiota was significantly different between Eµ-TCL1 and WT B6 mice.
Profiling was conducted using microbiome analysis to uncover intestinal changes related to leukemia.
These findings suggest potential links between gut health and chronic lymphocytic leukemia progression.

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Implication

Analysis shows differences in gut microbiota between Eµ-TCL1 and WT B6 mice, indicating dysbiosis linked to leukemia.

Abstract

Figure S2. Relative abundance of microbiota in Eµ-TCL1 mice versus WT B6 mice.

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Cite This Study

Skupa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd251 https://doi.org/10.1158/2767-9764.29917539

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
2Supplementary Figure S3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
3Supplementary Figure S6 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
4Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
5Supplementary Figure S5 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025