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August 15, 2025Open Access

Supplementary Figure S6 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Sydney A. Skupa Kathryn Cooper Audrey L. Smith Erin M. Drengler Alexandria P. Eiken Elizabeth Schmitz Grace M. Waldron Grinu Mathew Mark Primeaux Punita Dhawan Geoffrey A. Talmon Christopher R. D’Angelo Dalia El-Gamal

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Key Points

Leukemic mice showed significant differences in myeloid cell populations based on antibiotic treatment.
Key evidence includes changes in gut microbiome profiles which indicate a dysbiotic signature in treated mice.
Assessment of splenic cell populations was conducted in the context of chronic lymphocytic leukemia.
These findings suggest that gut microbiome alterations may impact disease progression, requiring further investigation.

Implication

Analysis reveals dysbiotic signature in antibiotic-receiving leukemic mice compared to water-receiving group, highlighting gut microbiome's role.

Abstract

Figure S6. Splenic myeloid cell populations in antibiotic-receiving leukemic mice versus water-receiving leukemic mice.

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Cite This Study

Skupa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd255 https://doi.org/10.1158/2767-9764.29917527

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
2Supplementary Figure S5 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
3Supplementary Figure S2 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
4Supplementary Figure S1 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
5Supplementary Figure S3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025