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August 15, 2025Open Access

Supplementary Figure S5 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Sydney A. Skupa Kathryn Cooper Audrey L. Smith Erin M. Drengler Alexandria P. Eiken Elizabeth Schmitz Grace M. Waldron Grinu Mathew Mark Primeaux Punita Dhawan Geoffrey A. Talmon Christopher R. D’Angelo Dalia El-Gamal

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Key Points

Dysbiotic signature identified in leukemic mice indicates significant T-cell functional changes.
Antibiotic treatment resulted in altered T-cell activity in leukemic mouse models, underscoring immunological impacts.
Study utilized gut microbiome profiling to analyze shifts in intestinal flora linked to chronic lymphocytic leukemia.
Findings suggest the gut microbiome plays a crucial role in T-cell modulation during leukemia progression.

Implication

Antibiotic-mediated ablation alters T-cell function in leukemic mice, suggesting a dysbiotic signature.

Abstract

Figure S5. Antibiotic-mediated gut microflora ablation alters T-cell function in leukemic mice.

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Cite This Study

Skupa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd270 https://doi.org/10.1158/2767-9764.29917530

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
2Supplementary Figure S7 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
3Supplementary Figure S6 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
4Supplementary Figure S2 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
5Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025