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August 15, 2025Open Access

Supplementary Figure S1 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Sydney A. Skupa Kathryn Cooper Audrey L. Smith Erin M. Drengler Alexandria P. Eiken Elizabeth Schmitz Grace M. Waldron Grinu Mathew Mark Primeaux Punita Dhawan Geoffrey A. Talmon Christopher R. D’Angelo Dalia El-Gamal

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Key Points

Dysbiotic signature indicates significant changes in gut microbiome associated with chronic lymphocytic leukemia.
Observed changes in gut microbiome were confirmed through continuous antibiotic delivery in the model.
Using Eμ-TCL1 mice allowed for in-depth investigation of intestinal changes due to chronic lymphocytic leukemia.
Findings support further exploration of gut microbiome roles in lymphocyte malignancies and disease progression.

Implication

Supplementary figure highlights gut microbiome alterations and a dysbiotic signature in Eμ-TCL1 mice, suggesting pathogenic links.

Abstract

Figure S1. Confirmation of continuous antibiotic delivery in the antibiotic-mediated gut microflora ablation model.

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Cite This Study

Skupa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd25d https://doi.org/10.1158/2767-9764.29917542

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
2Supplementary Figure S7 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
3Supplementary Figure S6 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
4Supplementary Figure S2 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025
5Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia2025