Supplementary Figure S3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Sydney A. Skupa; Kathryn Cooper; Audrey L. Smith; Erin M. Drengler; Alexandria P. Eiken; Elizabeth Schmitz; Grace M. Waldron; Grinu Mathew; Mark Primeaux; Punita Dhawan; Geoffrey A. Talmon; Christopher R. D’Angelo; Dalia El-Gamal

doi:10.1158/2767-9764.29917536

August 15, 2025Open Access

Supplementary Figure S3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

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Key Points

Intestinal changes occur alongside chronic lymphocytic leukemia, suggesting a dysbiotic signature.
Histopathological analysis highlights differences in the gut microbiome of Eμ-TCL1 mice with advanced CLL disease.
Assessment of the gut microbiome may reveal insights into the role of dysbiosis in CLL progression.
Findings point to a specific microbiome alteration linked to intestinal health in chronic lymphocytic leukemia.

Implication

Histopathological analysis reveals intestinal changes and a dysbiotic signature associated with CLL in Eμ-TCL1 mice, indicating potential microbiome involvement.

Abstract

Figure S3. Histopathological analysis of the intestinal tract of Eµ-TCL1 mice with advanced CLL disease.

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Cite This Study

Skupa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd254 https://doi.org/10.1158/2767-9764.29917536

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Supplementary Figure S3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S3 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

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