Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Sydney A. Skupa; Kathryn Cooper; Audrey L. Smith; Erin M. Drengler; Alexandria P. Eiken; Elizabeth Schmitz; Grace M. Waldron; Grinu Mathew; Mark Primeaux; Punita Dhawan; Geoffrey A. Talmon; Christopher R. D’Angelo; Dalia El-Gamal

doi:10.1158/2767-9764.29917533

August 15, 2025Open Access

Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

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Key Points

Intestinal barrier disturbances were evident in advanced chronic lymphocytic leukemia patients.
The gut microbiome analysis indicated a specific dysbiotic signature associated with the disease.
The study utilized Eμ-TCL1 mice to explore gut microbiome alterations and their implications.
Findings may suggest novel therapeutic approaches targeting gut health in chronic lymphocytic leukemia.

Implication

Profiling reveals intestinal barrier disturbances and a dysbiotic signature in Eμ-TCL1 mice with chronic lymphocytic leukemia, suggesting gut health impacts disease severity.

Abstract

Figure S4. Evidence of intestinal barrier disturbances in Eµ-TCL1 mice with advanced disease.

Discussion

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Cite This Study

Skupa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd263 https://doi.org/10.1158/2767-9764.29917533

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Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Key Points

Implication

Abstract

Discussion

Cite This Study

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