Figure 2 from Gut Microbiome Profiling in Eμ-TCL1 Mice Reveals Intestinal Changes and a Dysbiotic Signature Specific to Chronic Lymphocytic Leukemia

Compositional analysis of microbial communities as CLL disease progresses. A, LEfSe analysis demonstrating enrichment of specific bacterial taxa at the phylum level in transgenic Eμ-TCL1 mice (n = 12) and WT B6 mice (n = 10) at 12 months of age. LDA, linear discriminant analysis. B, Predicted microbial function pathways at the phylum level in transgenic Eμ-TCL1 mice and WT B6 mice at 12 months based on 16S rRNA sequencing data analyzed using ggPICRUSt2. ECM, extracellular matrix.