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September 2, 2025Open Access

Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai Yukari Nishito Hideaki Mizuno Noriko Motoi Nobuyoshi Hiraoka Masanori Fuse Yasuhito Arai Tatsuhiro Shibata Yukiko Sonobe Yoko Kayukawa Toru Maruyama Hironori Fukuda Yukihiro Mizoguchi Yukiko Aikawa Yukihiro Yoshida Shun‐ichi Watanabe Hiromi Sakamoto Makiko Yamashita Shigehisa Kitano Yuki Nagata Risa Mitsumori Kouichi Ozaki Shumpei Niida Yae Kanai Akiyoshi Hirayama Tomoyoshi Soga Teruhiko Yoshida Kazuki Yasuda Atsushi Ochiai Hiroyuki Tsunoda Kazunori Aoki

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Key Points

The study identifies a distinctive immunosuppressive microenvironment characterized by myeloid cell dominance.
Key findings indicate that these myeloid cells, specifically macrophages, play a substantial role in lung cancer progression.
The methodology involved generating and characterizing the phenotype of macrophages influenced by the EML4-ALK rearrangement.
This research highlights the potential for targeting myeloid cells in therapeutic strategies for lung cancer treatment.

Implication

Analysis reveals EML4-ALK rearrangement influences myeloid cell dominance in lung cancer, suggesting a unique immunosuppressive environment.

Abstract

Supplementary Figure S3. Method to generate macrophages and the phenotype of the macrophages.

Discussion

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5e1 https://doi.org/10.1158/2326-6066.30029209

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
2Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
3Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
4Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
5Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025

Supplementary Figure S11 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S10 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025