Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai; Yukari Nishito; Hideaki Mizuno; Noriko Motoi; Nobuyoshi Hiraoka; Masanori Fuse; Yasuhito Arai; Tatsuhiro Shibata; Yukiko Sonobe; Yoko Kayukawa; Toru Maruyama; Hironori Fukuda; Yukihiro Mizoguchi; Yukiko Aikawa; Yukihiro Yoshida; Shun‐ichi Watanabe; Hiromi Sakamoto; Makiko Yamashita; Shigehisa Kitano; Yuki Nagata; Risa Mitsumori; Kouichi Ozaki; Shumpei Niida; Yae Kanai; Akiyoshi Hirayama; Tomoyoshi Soga; Teruhiko Yoshida; Kazuki Yasuda; Atsushi Ochiai; Hiroyuki Tsunoda; Kazunori Aoki

doi:10.1158/2326-6066.30029179

Key Points

The presence of pd-1 and pd-l1 expressing cells was significantly linked to the eml4–alk rearrangement in lung cancer.
Immunohistochemical staining revealed prominent macrophage activity within the tumor microenvironment.
The study emphasizes the role of myeloid cells in fostering an immunosuppressive environment in lung cancer.
These findings indicate potential therapeutic targets for lung cancer associated with eml4–alk rearrangement.

Implication

Immunohistochemical analysis reveals a dominant presence of pd-1 and pd-l1 expressing cells in tumors, suggesting an immunosuppressive microenvironment.

Abstract

Supplementary Figure S9. Immunohistochemical (IHC) staining of PD-1+ and PD-L1+ cells, and macrophages in the tumor.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f66f https://doi.org/10.1158/2326-6066.30029179

View at Publisher

Ask AI

Bookmark

Share

Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading