Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

This is a Single-Cell RNA-Sequencing study.

Key Points

The research identifies a myeloid cell-dominant immunosuppressive microenvironment in lung cancer.
Key evidence shows altered CD8+ T cell-attractant chemokine gene expression from single-cell RNA-sequencing.
This involved single-cell RNA-sequencing analysis to examine the cancer microenvironment and immune interactions.
These findings may highlight potential therapeutic targets for enhancing T cell responses in lung cancer.

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Analysis demonstrates altered chemokine gene expression in myeloid cells within lung cancer, suggesting a role in T cell attraction.

Supplementary Figure S2. CD8+ T cell-attractant chemokine gene expression in UMAP plots of single-cell RNA-sequencing analysis.

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Arai et al. (2025) studied this question.

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