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September 2, 2025Open Access

Supplementary Figure S12 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai Yukari Nishito Hideaki Mizuno Noriko Motoi Nobuyoshi Hiraoka Masanori Fuse Yasuhito Arai Tatsuhiro Shibata Yukiko Sonobe Yoko Kayukawa Toru Maruyama Hironori Fukuda Yukihiro Mizoguchi Yukiko Aikawa Yukihiro Yoshida Shun‐ichi Watanabe Hiromi Sakamoto Makiko Yamashita Shigehisa Kitano Yuki Nagata Risa Mitsumori Kouichi Ozaki Shumpei Niida Yae Kanai Akiyoshi Hirayama Tomoyoshi Soga Teruhiko Yoshida Kazuki Yasuda Atsushi Ochiai Hiroyuki Tsunoda Kazunori Aoki

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Key Points

EML4-ALK rearrangement creates an immunosuppressive microenvironment in lung cancer, affecting treatment responses.
Activation of the RAS/MAPK/AP-1 pathway was confirmed to be linked with myeloid cell dominance.
Observational analysis identified the significance of myeloid cells in shaping the tumor's immune landscape.
Understanding this mechanism may enable strategies to overcome lung cancer's resistance to therapies.

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Implication

Findings demonstrate EML4-ALK activates the RAS/MAPK/AP-1 pathway in lung cancer, suggesting immunosuppressive effects.

Abstract

Supplementary Figure S12. EML4-ALK activates the RAS/MAPK/AP-1 signaling pathway.

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5c9 https://doi.org/10.1158/2326-6066.30029218

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
2Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
3Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
4Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
5Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025

Supplementary Figure S11 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025