Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai; Yukari Nishito; Hideaki Mizuno; Noriko Motoi; Nobuyoshi Hiraoka; Masanori Fuse; Yasuhito Arai; Tatsuhiro Shibata; Yukiko Sonobe; Yoko Kayukawa; Toru Maruyama; Hironori Fukuda; Yukihiro Mizoguchi; Yukiko Aikawa; Yukihiro Yoshida; Shun‐ichi Watanabe; Hiromi Sakamoto; Makiko Yamashita; Shigehisa Kitano; Yuki Nagata; Risa Mitsumori; Kouichi Ozaki; Shumpei Niida; Yae Kanai; Akiyoshi Hirayama; Tomoyoshi Soga; Teruhiko Yoshida; Kazuki Yasuda; Atsushi Ochiai; Hiroyuki Tsunoda; Kazunori Aoki

doi:10.1158/2326-6066.30029230

Key Points

The study reveals a distinctive immunosuppressive microenvironment driven by myeloid cells in lung cancer.
Findings indicate that the presence of EML4-ALK rearrangement correlates with an increase in myeloid cell populations.
Observational analysis evaluates immune cell types associated with EML4-ALK, highlighting their role in immune suppression.
Potential therapeutic avenues may arise from targeting the immunosuppressive effects of myeloid cells in lung cancer.

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Implication

Observational analysis identifies a myeloid cell-dominant immunosuppressive microenvironment in lung cancer, suggesting implications for targeted therapies.

Abstract

Supplementary Figure S1. Gating strategies for human immune cell types.

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5cc https://doi.org/10.1158/2326-6066.30029230

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Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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