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September 2, 2025Open Access

Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai Yukari Nishito Hideaki Mizuno Noriko Motoi Nobuyoshi Hiraoka Masanori Fuse Yasuhito Arai Tatsuhiro Shibata Yukiko Sonobe Yoko Kayukawa Toru Maruyama Hironori Fukuda Yukihiro Mizoguchi Yukiko Aikawa Yukihiro Yoshida Shun‐ichi Watanabe Hiromi Sakamoto Makiko Yamashita Shigehisa Kitano Yuki Nagata Risa Mitsumori Kouichi Ozaki Shumpei Niida Yae Kanai Akiyoshi Hirayama Tomoyoshi Soga Teruhiko Yoshida Kazuki Yasuda Atsushi Ochiai Hiroyuki Tsunoda Kazunori Aoki

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Key Points

Myeloid cells create an immunosuppressive environment that may aid lung cancer progression.
MDSC induction was observed in lung cancer, impacting how the immune system responds.
Analysis of cancer cell interactions was performed to explore the MDSC induction mechanism.
Understanding MDSC roles in lung cancer highlights potential therapeutic targets for treatment strategies.

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Implication

This analysis reveals MDSC induction by cancer cells in lung cancer, suggesting a distinct immunosuppressive role.

Abstract

Supplementary Figure S6. The strategy of MDSC induction by cancer cells.

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5e2 https://doi.org/10.1158/2326-6066.30029194

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
2Supplementary Figure S11 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
3Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
4Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
5Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025

Supplementary Figure S12 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025