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September 2, 2025

Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai Yukari Nishito Hideaki Mizuno Noriko Motoi Nobuyoshi Hiraoka Masanori Fuse Yasuhito Arai Tatsuhiro Shibata Yukiko Sonobe Yoko Kayukawa Toru Maruyama Hironori Fukuda Yukihiro Mizoguchi Yukiko Aikawa Yukihiro Yoshida Shun‐ichi Watanabe Hiromi Sakamoto Makiko Yamashita Shigehisa Kitano Yuki Nagata Risa Mitsumori Kouichi Ozaki Shumpei Niida Yae Kanai Akiyoshi Hirayama Tomoyoshi Soga Teruhiko Yoshida Kazuki Yasuda Atsushi Ochiai Hiroyuki Tsunoda Kazunori Aoki

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Key Points

Induced myeloid-derived suppressor cells (MDSC) significantly contribute to the immunosuppressive environment.
The presence of EML4-ALK rearrangement is linked with a distinctive immunosuppressive microenvironment.
Lung cancer patients with myeloid cell dominance often exhibit poorer immune responses.
The study emphasizes the role of myeloid cells in fostering cancer progression and immune evasion.

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Implication

Analysis reveals a myeloid cell–dominant immunosuppressive microenvironment in lung cancer, suggesting MDSC involvement.

Abstract

Supplementary Figure S7. The suppressive activity of induced MDSC.

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5e9 https://doi.org/10.1158/2326-6066.30029188

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
2Supplementary Figure S11 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
3Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
4Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
5Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025

Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S12 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025