Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai; Yukari Nishito; Hideaki Mizuno; Noriko Motoi; Nobuyoshi Hiraoka; Masanori Fuse; Yasuhito Arai; Tatsuhiro Shibata; Yukiko Sonobe; Yoko Kayukawa; Toru Maruyama; Hironori Fukuda; Yukihiro Mizoguchi; Yukiko Aikawa; Yukihiro Yoshida; Shun‐ichi Watanabe; Hiromi Sakamoto; Makiko Yamashita; Shigehisa Kitano; Yuki Nagata; Risa Mitsumori; Kouichi Ozaki; Shumpei Niida; Yae Kanai; Akiyoshi Hirayama; Tomoyoshi Soga; Teruhiko Yoshida; Kazuki Yasuda; Atsushi Ochiai; Hiroyuki Tsunoda; Kazunori Aoki

doi:10.1158/2326-6066.30029203

Key Points

The eml4-alk rearrangement creates an immunosuppressive microenvironment, dominating with myeloid cells in lung cancer.
Dendritic cell markers and cd8+ t cell-attractant chemokines were significantly affected by gm-csf in macrophages.
The findings suggest a complex interaction between myeloid cells and the immune response in lung cancer.
Understanding this microenvironment could lead to new therapeutic strategies targeting myeloid cell activity.

Implication

Supplementary figure illustrates the role of gm-csf in promoting myeloid cells and cd8+ t cell chemokines in lung cancer, indicating an immunosuppressive environment.

Abstract

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f5fe https://doi.org/10.1158/2326-6066.30029203

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Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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