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September 2, 2025Open Access

Supplementary Figure S8 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer

Kosuke Arai Yukari Nishito Hideaki Mizuno Noriko Motoi Nobuyoshi Hiraoka Masanori Fuse Yasuhito Arai Tatsuhiro Shibata Yukiko Sonobe Yoko Kayukawa Toru Maruyama Hironori Fukuda Yukihiro Mizoguchi Yukiko Aikawa Yukihiro Yoshida Shun‐ichi Watanabe Hiromi Sakamoto Makiko Yamashita Shigehisa Kitano Yuki Nagata Risa Mitsumori Kouichi Ozaki Shumpei Niida Yae Kanai Akiyoshi Hirayama Tomoyoshi Soga Teruhiko Yoshida Kazuki Yasuda Atsushi Ochiai Hiroyuki Tsunoda Kazunori Aoki

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Key Points

Myeloid cells dominate the immunosuppressive microenvironment in lung cancer.
Findings indicate that the presence of EML4–ALK rearrangement affects tumor immune response.
Assessment used gating strategies for mouse immune cell types to identify distinct populations.
These insights may inform future therapeutic approaches targeting the immune environment.

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Implication

Observational analysis reveals an immunosuppressive microenvironment in lung cancer, highlighting the role of myeloid cells.

Abstract

Supplementary Figure S8. Gating strategies for mouse immune cell types.

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Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68c182609b7b07f3a060f612 https://doi.org/10.1158/2326-6066.30029185

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S1 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
2Supplementary Figure S2 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
3Supplementary Figure S4 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
4Supplementary Figure S3 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
5Supplementary Figure S6 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025

Supplementary Figure S7 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S9 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025
Supplementary Figure S12 from EML4–ALK Rearrangement Creates a Distinctive Myeloid Cell–Dominant Immunosuppressive Microenvironment in Lung Cancer2025