Figure S6 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression

Key Points

Tumor growth suppression occurs due to the depletion of fumarate from metabolic stress.
Mitophagy is identified as a key mechanism driving tumor suppression in head and neck squamous cell carcinoma (HNSCC).
Experimental analysis utilized LCL768 to assess its effects on UM-SCC-1A-derived xenograft models.
Findings point to the importance of ceramide in regulating metabolic processes related to tumor growth.

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In vivo analysis shows that metabolic stress depletes fumarate in HNSCC tumors, suggesting mitophagy plays a role in tumor suppression.

Effects of LCL768 on the growth of UM-SCC-1A-derived xenograft HNSCC tumors in vivo.

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Oleinik et al. (2025) studied this question.

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