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September 2, 2025Open Access

Figure S4 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression

Natalia V. Oleinik Firdevs Cansu Atilgan Mohamed Faisal Kassir Han Gyul Lee Alhaji H. Janneh Wyatt Wofford Chase Walton Zdzisław M. Szulc Elizabeth G. Hill Alexander V. Alekseyenko Hüseyin Çimen Jessica H. Hartman Christina Voelkel‐Johnson Michael B. Lilly John J. Lemasters Norma Frizzell Xue‐Zhong Yu Shikhar Mehrotra Besim Öğretmen

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Key Points

Metabolic stress linked to ceramide depletion drives mitophagy, aiding tumor suppression.
Drp1 mutations affect mitochondrial interactions, altering cancer metabolism through LCL768.
The findings suggest a novel connection between metabolic changes and tumor dynamics.
The study's implications may enhance therapeutic strategies targeting cancer metabolism.

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Implication

Observational analysis reveals metabolic stress alters mitochondrial interactions, suggesting implications for cancer therapy.

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Cite This Study

Oleinik et al. (2025) studied this question.

synapsesocial.com/papers/68c183f09b7b07f3a060f739 https://doi.org/10.1158/0008-5472.30029488

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S3 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
2Figure S1 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
3Figure S5 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
4Figure S7 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
5Table S1 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
6Figure S6 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
7Supplementary Figure S2 from Alzheimer's Disease–Associated Amyloid-β Precursor Protein Prevents Aging Stress–Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity2025
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