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September 2, 2025Open Access

Figure S3 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression

Natalia V. Oleinik Firdevs Cansu Atilgan Mohamed Faisal Kassir Han Gyul Lee Alhaji H. Janneh Wyatt Wofford Chase Walton Zdzisław M. Szulc Elizabeth G. Hill Alexander V. Alekseyenko Hüseyin Çimen Jessica H. Hartman Christina Voelkel‐Johnson Michael B. Lilly John J. Lemasters Norma Frizzell Xue‐Zhong Yu Shikhar Mehrotra Besim Öğretmen

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Key Points

Mitophagy is significantly induced by ceramide, contributing to tumor suppression mechanisms.
Fumarate depletion was observed alongside the induction of mitophagy in the presence of metabolic stress.
The process is independent of p17 and specific cell lines, indicating a broad applicability of the findings.
Drp1's nitrosylation plays a critical role in the metabolic response related to mitophagy induction.

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Implication

Research reveals mitophagy's role in tumor suppression through metabolic stress and Drp1's nitrosylation.

Abstract

LCL768-mediated mitophagy is independent of p17, cell line, and induces Drp1’s nitrosylation.

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Cite This Study

Oleinik et al. (2025) studied this question.

synapsesocial.com/papers/68c183f09b7b07f3a060f723 https://doi.org/10.1158/0008-5472.30029491

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S1 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression2025
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