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September 2, 2025Open Access

Table S1 from Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression

Natalia V. Oleinik Firdevs Cansu Atilgan Mohamed Faisal Kassir Han Gyul Lee Alhaji H. Janneh Wyatt Wofford Chase Walton Zdzisław M. Szulc Elizabeth G. Hill Alexander V. Alekseyenko Hüseyin Çimen Jessica H. Hartman Christina Voelkel‐Johnson Michael B. Lilly John J. Lemasters Norma Frizzell Xue‐Zhong Yu Shikhar Mehrotra Besim Öğretmen

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Key Points

Ceramide-induced metabolic stress drives mitophagy, leading to tumor suppression.
The depletion of fumarate is a key mechanism in this metabolic process.
Analysis explores the relationship between cellular stress responses and tumor behavior.
Findings indicate potential for leveraging metabolic pathways in cancer therapies.

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Implication

Research shows that ceramide enhances mitophagy via fumarate depletion in tumors, suggesting a potential therapeutic pathway.

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Cite This Study

Oleinik et al. (2025) studied this question.

synapsesocial.com/papers/68c183f09b7b07f3a060f747 https://doi.org/10.1158/0008-5472.30029476

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