Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi; Li Dai; Marisa Maisiak; Sunmin Lee; Elizabeth Lopez; Takeshi Itoh; Len Neckers

doi:10.1158/1541-7786.30050538

September 4, 2025Open Access

Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

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Key Points

TRAP1 deletion drives glutamine addiction in tumor cells, destabilizing the antiporter SLC7A11/xCT.
This study highlights the importance of mitochondrial dynamics in regulating glutamine metabolism in tumors.
The findings suggest that targeting TRAP1 could provide therapeutic benefits in cancer treatment.
Further investigation is needed to understand the full implications of antiporter destabilization in tumor biology.

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Implication

Research reveals mitochondrial hsp90 paralog TRAP1 deletion drives glutamine addiction in tumor cells, indicating a key role of the antiporter SLC7A11/xCT.

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Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a0615406 https://doi.org/10.1158/1541-7786.30050538

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Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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