⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

September 4, 2025Open Access

Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

View Full Paper

Ask AI

Bookmark

Share

Key Points

TRAP1 deletion drives glutamine addiction in tumor cells and destabilizes the SLC7A11/xCT antiporter.
HCT116 cells exhibited altered metabolism with 13C Glc tracing data showing significant shifts between WT and TRAP1 KO.
Observational analysis of metabolic changes was conducted using glutamine tracing techniques in tumor cells.
Findings suggest that targeting the SLC7A11/xCT pathway may offer new therapeutic options for tumors reliant on glutamine.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Examination reveals TRAP1 deletion drives glutamine addiction in tumor cells, indicating a role for SLC7A11/xCT instability.

Abstract

This table has 13C Glc tracing data for WT and TRAP1 KO HCT116 cells

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18f2a9b7b07f3a061540e https://doi.org/10.1158/1541-7786.30050553

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary File 4: Table 4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary File 3: Table 3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary Figure S2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025