⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

September 4, 2025Open Access

Supplementary Figure S1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

View Full Paper

Ask AI

Bookmark

Share

Key Points

TRAP1 deletion increases glutamine addiction in tumor cells, highlighting a crucial metabolic dependency.
The study reveals that disrupting SLC7A11/xCT significantly contributes to altered glutamine levels in cancer.
Generation of TRAP1 knockout cells utilized CRISPR/Cas9 for precise gene targeting and analysis.
This research suggests potential new avenues for targeting metabolic pathways in cancer therapies.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Implication

Observational analysis shows glutamine addiction increases in tumor cells lacking TRAP1, highlighting SLC7A11's destabilization.

Abstract

Generation of TRAP1 KO cells using CRISPR/Cas9

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148a5 https://doi.org/10.1158/1541-7786.30050568

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary Figure S3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary Figure S5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025