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September 4, 2025Open Access

Supplementary Figure S4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

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Key Points

TRAP1 deletion drives glutamine addiction in tumor cells through the destabilization of SLC7A11/xCT, pointing to possible therapeutic targets.
Key evidence includes the comparison of erastin treatments and xCT overexpression in tumor cells, indicating metabolic vulnerabilities.
The method involved observational analysis comparing treatment effects on glutamine metabolism and antiporter function.
This finding highlights potential metabolic targets for cancer therapies, but further investigation is warranted in clinical settings.

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Implication

Observational analysis reveals glutamine addiction linked to TRAP1 deletion in tumor cells, suggesting implications for cancer therapy.

Abstract

OCR traces comparing erastin treatments and xCT overexpression

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Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a061492b https://doi.org/10.1158/1541-7786.30050559

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary Figure S2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary Figure S5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary Figure S1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025

Supplementary File 4: Table 4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025