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September 4, 2025Open Access

Supplementary Figure S3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

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Key Points

TRAP1 deletion results in increased glutamine addiction in tumor cells, suggesting metabolic implications.
Key evidence shows destabilization of the SLC7A11/xCT antiporter in TRAP1 knockout cells.
Observational analysis across multiple cell lines reveals altered expression of SLC7A11/xCT following TRAP1 deletion.
Potential therapeutic target emerges as TRAP1 modulation may affect tumor metabolism and growth.

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Implication

Findings demonstrate TRAP1 deletion destabilizes the SLC7A11/xCT antiporter in tumor cells, highlighting glutamine addiction.

Abstract

SLC7A11/xCT expression in HEK293T, UMUC3 and PC3 TRAP1 KO cells

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Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a0614974 https://doi.org/10.1158/1541-7786.30050562

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure S5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary Figure S2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary Figure S1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary File 3: Table 3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025