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September 4, 2025Open Access

Supplementary File 3: Table 3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

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Key Points

TRAP1 deletion drives glutamine addiction in tumor cells, affecting cellular metabolism.
Cystine/glutamate antiporter SLC7A11/xCT shows destabilization in TRAP1 knockout cells.
Analysis includes 13C glutamine tracing data for wild-type and TRAP1 knockout UMUC3 cells.
Findings suggest targeting TRAP1 may provide new therapeutic approaches in cancer treatment.

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Implication

Analysis reveals TRAP1 deletion enhances glutamine addiction in tumor cells, indicating effects on SLC7A11/xCT.

Abstract

This table has 13C Gln tracing data for WT and TRAP1 KO UMUC3 cells

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Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c089b7b07f3a06148e1 https://doi.org/10.1158/1541-7786.30050547

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary File 4: Table 4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary Figure S3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary Figure S2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025